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Dosing considerations xplode software Sildenafil belongs to a class of medications called phosphodiesterase inhibitors, which work by increasing blood flow to the penis during sexual activity, resulting in an erection. Viagra (sildenafil) is used for the treatment of erectile dysfunction. Viagra works by inhibiting the chemical phosphodiesterase, which leads to an increase in the effect of nitric oxide. Nitric oxide allows the smooth muscles inside the penis to relax, promoting more blood flow to the area during sexual arousal or stimulation. Viagra begins to work within about an hour and the effects can last for up to four hours. In clinical studies, Viagra was given to more than 3,000 patients aged 19 to 87 years with erectile dysfunction of different causes. Men with Renal ImpairmentYou should not take CIALIS more than once a day.Animal studies showed vascular inflammation in tadalafil-treated mice, rats, and dogs. In mice and rats, lymphoid necrosis and hemorrhage were seen in the spleen, thymus, and mesenteric lymph nodes at unbound tadalafil exposure of 2- to 33-fold above the human exposure (AUCs) at the MRHD of 20 mg. In dogs, an increased incidence of disseminated arteritis was observed in 1- and 6-month studies at unbound tadalafil exposure of 1- to 54-fold above the human exposure (AUC) at the MRHD of 20 mg. In a 12-month dog study, no disseminated arteritis was observed, but 2 dogs exhibited marked decreases in white blood cells (neutrophils) and moderate decreases in platelets with inflammatory signs at unbound tadalafil exposures of approximately 14- to 18-fold the human exposure at the MRHD of 20 mg. The abnormal blood-cell findings were reversible within 2 weeks after stopping treatment.

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Myalgia 1% 1% 4% 3%The primary efficacy and safety study conducted outside the US included 268 patients, with a mean age of 56 years (range 21 to 78 years). The population was 86% White, 3% Black, 0.4% Hispanic, and 10% of other ethnicities, and included patients with ED of various severities, etiologies (organic, psychogenic, mixed), and with multiple co-morbid conditions, including diabetes mellitus, hypertension, and other cardiovascular disease. Ninety-three percent of patients reported ED of at least 1-year duration. slow speech

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